In this engaging and thought-provoking episode, Kris Tyte and Sean Snodgrass embark on a journey through cutting-edge topics like CRISPR gene editing, reverse aging, and future DNA-based medicine. From deep dives into calorie science and food addictions to humorous reflections on politics, radio personalities, catfishing, and societal shortcuts. No topic is too big (or too random) for this free-flowing and insightful discussion. This conversation also touches on human sexuality, complexities revolving around judgment and identity, and the psychological impact certain words can have.
Follow Up Notes
Discussion of CRISPR gene editing tools that can do individual base edits and point mutations to cure diseases, including successful treatment of a little girl's leukemia using engineered T-cells.
Follow Up Notes
Vision of future medicine where people get their DNA fully sequenced and whatever corrections need to be made are implemented, like getting a genetic tune-up.
Quotable
“When we age our telomeres start to shrink. It's like cutting the end off of a shoelace. So slowly just shaving leaving it bit by bit.
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Analogy explaining how telomeres shorten with age, potentially addressable through future genetic restoration using younger DNA.
Diagram illustrating CRISPR gene editing process, showing how it can make precise changes to DNA sequences. Photo credits: https://labassociates.com/crispr-a-gene-editing-tool
Follow Up Notes
Discussion of curing sickle cell anemia through gene editing, noting the mutation originally protected against malaria but causes pain when malaria is no longer a threat.
Quotable
“What if you were to reactive a person's youth hormones like the phase their prepubescent like their youthful exuberance, energy and all that. Like reactivate that phase in someone's life.
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Hypothetical scenario of reactivating youthful energy and hormones in adults through genetic manipulation.
Follow Up Notes
Discussion of foods that require more energy to process than they provide, like celery, cabbage stews, and water; creating a caloric deficit.
Photo comparing kilocalories (kcal) with calories (cal), highlighting the difference in energy units and their relevance to food consumption and metabolism.
Follow Up Notes
Comparison of how large-scale numbers in government spending become abstractions that human minds can't properly comprehend, similar to food calorie scaling.
Quotable
“The only way that it's ever going to change if the public just turns their back and says, we don't care at all anymore about anything you have to say.”
Proposed solution to celebrity grift culture: complete public disengagement from fame-for-fame's-sake personalities.
Quotable
“Like you don't have to advertise anything about the functionality or whatever the product you just make people laugh, right? There's like commercials now that just are humorous and that's it.
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Observation about evolution of advertising toward pure entertainment value rather than product functionality.
Follow Up Notes
Discussion of casein protein in milk products and how substances ending in "-ine" (nicotine, morphine, heroin) tend to bind to brain receptors.
Gluten and dairy are like addictive drugs to the brain
Article explaining how gluten and dairy can act as addictive substances in the brain.
Follow Up Notes
Introduction of concept that intelligence can be sexually attractive.
Quotable
“The problem is that society has all these different labels and identities and concepts and social groups all spun up around all this idea of human sexuality.
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Beginning of philosophical discussion about human sexuality being uniquely individual rather than categorizable.
Quotable
“Every single person's sexuality is 100% unique fingerprint to them. And so there's no reason to worry about any kind of labels or any kind of pejorative.
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Core philosophy that each person's sexuality is completely unique and shouldn't be subject to limiting labels.
Quotable
“It's so easy to kind of cross your arms and snarl at the world right through judgmentally and take yourself back for no reason or limit those opportunities.
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Warning against judgmental attitudes that limit personal growth and meaningful connections.
Follow Up Notes
Description of how political parties use focus groups with dial testing to gauge emotional reactions to words and phrases for speech optimization.
Quotable
“These shortcuts I think what some people do is they cherry pick them to act in their diabolical way and use them as hot buttons in their populist speech.
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Critique of how societal shortcuts and loaded language are manipulated for political purposes.
Follow Up Notes
Quick mental or cultural labels or categories that people use to simplify complex realities about groups, behaviors, or ideas.
Follow Up Notes
Discussion of potential future where cash becomes illegal and all transactions must be recorded, implemented through inconvenience rather than outright bans.
Quotable
“You create dark patterns in society or a website or anything people interact with to make it less likely to happen or more likely to happen.
”
Explanation of how behavioral manipulation works through interface design and social structures.
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